Acute Pulmonary Embolism: A Challenge for Hemostasiology by N. W. März, M. Nauck, H. Wieland (auth.), Dr. A. Geibel,

By N. W. März, M. Nauck, H. Wieland (auth.), Dr. A. Geibel, Prof. Dr. H. Just, Dr. med. W. Kasper, Dr. S. Konstantinides (eds.)

The worth of echocardiography within the diagnostic work-up of sufferers with suspected acute pulmonary embolism.- New advancements within the thrombolytic remedy of venous thrombosis.- Mechanism of blood coagulation. more moderen elements of anticoagulant and antithrombotic therapy.- MR-angiography within the analysis of pulmonary embolism.- Scintigraphy-ventilation/perfusion scanning and imaging of the embolus.- scientific path and analysis of acute pulmonary embolism.- The molecular mechanisms of inherited thombophilia.

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If patients were more systematically screened for impairment of their homocysteine metabolism, more of the idiopathic thromboses may be explainable. The same is true for antiphospholipid antibodies. If the prevalence of 14 % in unselected patients presenting with venous thrombosis reported by Ginsberg et al. [43] is confirmed, then antiphospholipid antibodies may explain a significant number of the yet unexplainable idiopathic thromboses. With more frequent application of molecular genetic testing, new risk factors for venous thrombosis are being discovered.

Hursting MJ, Butman BT, Steiner JP et al. (1993) Monoclonal antibodies specific for prothrombin fragment 1,2 and their use in a quantitative enzyme-linked immunosorbent assay. Clin Chern 39: 583-591 13. Katus HA, Loser S, Hallermayer K et al. (1992) Development and in vitro characterization of a new immunoassay of cardiac troponin T. Clin Chern 38: 386-393 14. Marder VJ (1990) What does the "dimer test" test? Circulation 82: 1514-1515 15. Merlini PA, Bauer KA, Oltrona L, Ardissino D, Cattaneo M, Belli C, Mannucci PM, Rosenberg RD (1994) Persistent activation of coagulation mechanism in unstable angina and myocardial infarction.

W. Heller· 1. Seipel Medizinische Universitatsklinik Abteilung Innere Medizin III Otfried-Miiller-StraBe 10 72076 Tiibingen, Germany 27 Clinical implications of the new understanding of thrombophilia S. Moll, D. Gulba Summary Thrombophilia used to be viewed as a disorder caused by a single congenital thrombophilic abnormality with thrombosis often triggered by an exogenous risk situation. It is becoming clear, however, that it is often a compound state with several congenital and acquired thrombophilic abnormalities.

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